One area where htmx apps lag behind SPAs is interaction delay. While htmx apps usually have a much improved initial load time, the need for a server roundtrip for most interactions is a disadvantage.
For most apps, this doesn’t matter, as they are all frontends to databases anyway. Thus, there is always a request to the server; the difference is whether the response is HTML or a proprietary JSON-based format that needs to be converted to HTML.
The latency issue is even less of a problem thanks to… let’s call it Application on CDN (AoCDN).
The common term for this technology is
AoCDN is a service offered by some hosting and CDN providers. It means that your code runs on several servers all across the world, close to the user.